HORDB

ID: hor002338
Uniprot ID: P11924
Protein name: Califin-B small subunit
Gene name: NA
Organism: Aplysia californica (California sea hare)
Family: Molluscan ELH family
Source: animal
Expression: atrial gland
Disease: NA
Comments: NA
Taxonomy: Aplysia (genus), Aplysiidae (family), Aplysioidea (superfamily), Aplysiida (order), Tectipleura, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Function: Excites LB and LC cells of the abdominal ganglion and cause egg-laying
Mechanism: Califin B probably derives from polyprotein B, which is also the precursor for peptide B.
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002338_AF2.pdb

hor002338_ESM.pdb

Mass:	221247	Formula:	C79H125N23O30S
Absent amino acids:	AEHIKMQTWY	Common amino acids:	DLS
pI:	3.83	Basic residues:	1
Polar residues:	8	Hydrophobic residues:	5
Hydrophobicity:	-32.78	Boman Index:	-3962
Half-Life:	1.1 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	81.11
Instability Index:	1414.44	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 3753705
Title: Isolation and primary structure of the califins, three biologically active egg-laying hormone-like peptides from the atrial gland of Aplysia californica